Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η6-p-cymene)Ru(NS)Cl]+ (NS=9-anthraldehyde thiosemicarbazones)

被引：78

作者：

Beckford, Floyd A. ^{[1
]}

Leblanc, Gabriel ^{[1
]}

Thessing, Jeffrey ^{[1
]}

Shaloski, Michael, Jr. ^{[1
]}

Frost, Brian J. ^{[2
]}

Li, Liya ^{[3
]}

Seeram, Navindra P. ^{[3
]}

机构：

[1] Lyon Coll, Div Sci, Batesville, AR 72501 USA

[2] Univ Nevada, Dept Chem, Reno, NV 89557 USA

[3] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2009年 / 12卷 / 11期

关键词：

Thiosemicarbazones; Ruthenium-arene complex; DNA interaction; Viscometry; Cytotoxicity; Structure elucidation; DNA-BINDING PROTEINS; A-TYPE COMPLEXES; NICKEL(II) COMPLEXES; ANTITUMOR-ACTIVITY; ARENE COMPLEXES; IN-VITRO; CISPLATIN; CANCER; INHIBITION; RESISTANCE;

D O I：

10.1016/j.inoche.2009.08.034

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC=9-anthraldehyde thiosemicarbazone and R=H, CH3 and C6H5). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene-ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：1094 / 1098

页数：5

共 34 条

[1]

Ovarian cancer: Strategies for overcoming resistance to chemotherapy [J].