Protein kinase C in the postmortem brain of teenage suicide victims

被引：69

作者：

Pandey, GN ^{[1
]}

Dwivedi, Y ^{[1
]}

Pandey, SC ^{[1
]}

Conley, RR ^{[1
]}

Roberts, RC ^{[1
]}

Tamminga, CA ^{[1
]}

机构：

[1] MARYLAND PSYCHIAT RES CTR, BALTIMORE, MD 21228 USA

来源：

NEUROSCIENCE LETTERS | 1997年 / 228卷 / 02期

关键词：

protein kinase C; postmortem brain; teenage suicide;

D O I：

10.1016/S0304-3940(97)00378-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increased serotonin(2A) (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [H-3]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [H-3]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B-max of [H-3]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：111 / 114

页数：4

共 31 条

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