The effect of stimulation interval on plasticity following repeated blocks of intermittent theta burst stimulation

被引:75
作者
Tse, Nga Yan [1 ,2 ]
Goldsworthy, Mitchell R. [3 ]
Ridding, Michael C. [3 ]
Coxon, James P. [4 ]
Fitzgerald, Paul B. [5 ,6 ]
Fornito, Alex [1 ,2 ]
Rogasch, Nigel C. [1 ,2 ]
机构
[1] Monash Univ, Monash Inst Cognit & Clin Neurosci, Sch Psychol Sci, Brain & Mental Hlth Res Hub, Melbourne, Vic, Australia
[2] Monash Univ, Monash Biomed Imaging, Melbourne, Vic, Australia
[3] Univ Adelaide, Adelaide Med Sch, Robinson Res Inst, Neuromotor Plast & Dev, Adelaide, SA, Australia
[4] Monash Univ, Monash Inst Cognit & Clin Neurosci, Sch Psychol Sci, Melbourne, Vic, Australia
[5] Monash Univ, Epworth Healthcare, Epworth Clin, Melbourne, Vic, Australia
[6] Monash Univ, Cent Clin Sch, Monash Alfred Psychiat Res Ctr, Melbourne, Vic, Australia
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
HUMAN MOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; LONG-TERM POTENTIATION; LTD-LIKE PLASTICITY; INTERINDIVIDUAL VARIABILITY; INTRACORTICAL INHIBITION; CORTICAL EXCITABILITY; SYNAPTIC PLASTICITY; SUBJECT VARIABILITY; BRAIN-STIMULATION;
D O I
10.1038/s41598-018-26791-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
This study assessed the effect of interval duration on the direction and magnitude of changes in cortical excitability and inhibition when applying repeated blocks of intermittent theta burst stimulation (iTBS) over motor cortex. 15 participants received three different iTBS conditions on separate days: single iTBS; repeated iTBS with a 5 minute interval (iTBS-5-iTBS); and with a 15 minute interval (iTBS-15-iTBS). Changes in cortical excitability and short-interval cortical inhibition (SICI) were assessed via motor-evoked potentials (MEPs) before and up to 60 mins following stimulation. iTBS-15-iTBS increased MEP amplitude for up to 60 mins post stimulation, whereas iTBS-5-iTBS decreased MEP amplitude. In contrast, MEP amplitude was not altered by single iTBS. Despite the group level findings, only 53% of individuals showed facilitated MEPs following iTBS-15-iTBS, and only 40% inhibited MEPs following iTBS-5-iTBS. Modulation of SICI did not differ between conditions. These results suggest interval duration between spaced iTBS plays an important role in determining the direction of plasticity on excitatory, but not inhibitory circuits in human motor cortex. While repeated iTBS can increase the magnitude of MEP facilitation/inhibition in some individuals compared to single iTBS, the response to repeated iTBS appears variable between individuals in this small sample.
引用
收藏
页数:10
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