New DNA-sensing pathway feeds RIG-I with RNA

被引：20

作者：

Cao, Xuetao ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai, Peoples R China

[2] Second Mil Med Univ, Inst Immunol, Shanghai, Peoples R China

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 10期

关键词：

INNATE IMMUNITY; CYTOSOLIC DNA; CELLS; INTERFERONS; INDUCE; BETA;

D O I：

10.1038/ni1009-1049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytosolic DNA sensors have remained poorly defined so far. Two recent studies identify a previously undefined cytosolic DNA-sensing pathway that depends on the RNA polymerase III-mediated conversion of microbial DNA into 5'-triphosphate double-stranded RNA that activates the RNA helicase RIG-I.

引用

页码：1049 / 1051

页数：4

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