Candidate Gene Polymorphisms for Ischemic Stroke

被引：59

作者：

Matarin, Mar ^{[2
]}

Brown, W. Mark ^{[4
]}

Dena, Hernandez ^{[3
]}

Britton, Angela ^{[2
]}

De Vrieze, Fabienne Wavrant ^{[3
]}

Brott, Thomas G. ^{[1
]}

Brown, Robert D., Jr. ^{[5
]}

Worrall, Bradford B. ^{[6
,7
]}

Case, L. Douglas ^{[4
]}

Chanock, Stephen J. ^{[8
]}

Metter, E. Jeffrey ^{[9
]}

Ferruci, Luigi ^{[9
]}

Gamble, Dale ^{[1
]}

Hardy, John A. ^{[10
]}

Rich, Stephen S. ^{[11
]}

Singleton, Andrew ^{[2
,3
]}

Meschia, James F. ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[2] NIA, Mol Genet Sect, NIH, Bethesda, MD 20892 USA

[3] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[4] Wake Forest Univ, Med Ctr, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[7] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[8] NCI, Adv Technol Ctr, Gaithersburg, MD USA

[9] NIA, Longitudinal Studies Sect, Intramural Res Program, Bethesda, MD USA

[10] UCL, Inst Neurol, Dept Mol Neurosci, London, England

[11] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

来源：

STROKE | 2009年 / 40卷 / 11期

基金：

美国国家卫生研究院;

关键词：

candidate genes; genetics; ischemic stroke; RISK; ASSOCIATION; EPIDEMIOLOGY; DISEASE;

D O I：

10.1161/STROKEAHA.109.558015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Ischemic stroke (IS) is a multifactorial disorder with strong evidence from twin, family, and animal model studies suggesting a genetic influence on risk and prognosis. Several candidate genes for IS have been proposed, but few have been replicated. We investigated the contribution of 67 candidate genes (369 single nucleotide polymorphisms [SNPs]) on the risk of IS in a North American population of European descent. Methods-Two independent studies were performed. In the first, 342 SNPs from 52 candidate genes were genotyped in 307 IS cases and 324 control subjects. The SNPs significantly associated with IS were tested for replication in another cohort of 583 IS cases and 270 control subjects. In the second study, 212 SNPs from 62 candidate genes were analyzed in 710 IS cases with subtyping available and 3751 control subjects. Results-None of the candidate genes (SNPs) were significantly associated with IS risk independent of known stroke risk factors after correction for multiple hypotheses testing. Conclusion-These results are consistent with previous meta-analyses that demonstrate an absence of genetic association of variants in plausible candidate genes with IS risk. Our study suggests that the effect of the investigated SNPs may be weak or restricted to specific populations or IS subtypes. (Stroke. 2009; 40: 3436-3442.)

引用

页码：3436 / 3442

页数：7

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