Cardiac development in zebrafish: coordination of form and function

被引:186
作者
Glickman, NS
Yelon, D [1 ]
机构
[1] NYU, Sch Med, Dev Genet Program, New York, NY 10016 USA
[2] NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
cardiac development; cardiac fusion; heart tube; morphogenesis; zebrafish;
D O I
10.1016/S1084952102001040
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Organogenesis is a dynamic process involving multiple phases of pattern formation and morphogenesis. For example, heart formation involves the specification and differentiation of cardiac precursors, the integration of precursors into a tube, and the remodeling of the embryonic tube to create a fully functional organ. Recently, the zebrafish has emerged as a powerful model organism for the analysis of cardiac development. In particular, zebrafish mutations have revealed specific genetic requirements for cardiac fate determination, migration, fusion, tube assembly, looping, and remodeling. These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis.
引用
收藏
页码:507 / 513
页数:7
相关论文
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