The preparation of a fully differentiated "multiwarhead" siderophore precursor

被引：28

作者：

Murray, AP ^{[1
]}

Miller, MJ ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 01期

关键词：

D O I：

10.1021/jo026391c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protected, fully differentiated siderophore analogue has been prepared so that "Trojan Horse" -like siderophore drug conjugates with different drugs can be synthesized. The key steps in the synthesis include controlled preparation of an unsymmetrical urea and its conversion to a fully differentiated isocyanurate by reaction with chloro(carbonyl) isocyanate.

引用

页码：191 / 194

页数：4

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