Effect of drug, formulation and process variables on granulation and compaction characteristics of heterogeneous matrices .1. HPMC and HPC systems

被引:17
作者
Ebube, NK
Hikal, AH
Wyandt, CM
Beer, DC
Miller, LG
Jones, AB
机构
[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACEUT,UNIVERSITY,MS 38677
[2] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677
[3] SCHERING PLOUGH CORP,HEALTHCARE PROD DIV,MEMPHIS,TN 38105
关键词
acetaminophen; co-active; compaction characteristics; heterogeneous matrix; pseudoephedrine;
D O I
10.1016/S0378-5173(97)00180-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The purpose of this study was to investigate the effects of hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) ratios, total polymer loading and the use of pseudoephedrine as a co-active on the physical properties of acetaminophen granulation as well as that of the compressed tablets, The incorporation of pseudoephedrine to the acetaminophen-polymer formulations resulted in a decreased amount of water required for the wet granulation process. Moreover, the particle size of the granules decreased and the tablet hardness increased. Increasing the HPMC-to-HPC ratio increased both the particle size of granules and the tablet hardness. No clear trend in the particle size of granules and the tablet hardness was seen when the total polymer loading was varied at a given HPMC-to-HPC ratio. The tablet disintegration time was not influenced by the presence of pseudoephedrine; however, it decreased for the formulations containing a lower total polymer content. All the matrix systems investigated showed good compressibility. The effect of pseudoephedrine on the physical properties of wet granulated or compressed acetaminophen tablets was attributed to interference in the hydration characteristics of the matrix polymers. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:49 / 57
页数:9
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