A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules

被引：589

作者：

Cosman, D

Fanger, N

Borges, L

Kubin, M

Chin, W

Peterson, L

Hsu, ML

机构：

[1] Immunex Corporation, Seattle, WA 98101

来源：

IMMUNITY | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(00)80529-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human cytomegalovirus UL18 gene product is a homolog of cellular major histocompatibility (MHC) class I antigens. UL18 has been proposed to protect virus-infected cells against natural killer (NK) cell cytotoxicity by engaging NK cell killer inhibitory receptors (KIR) for MHC class I. UL18 binds to a novel immunoglobulin superfamily glycoprotein, designated Leukocyte Immunoglobulin-like Receptor (LIR-1). This protein is distinct from, but related to, known KIRs and binds cellular MHC class I antigens. The cytoplasmic domain of LIR-1 contains four putative immunoreceptor tyrosine-based inhibitory motifs. Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function.

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收藏

页码：273 / 282

页数：10

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