Anti-herpetic activity of various medicinal plant extracts

被引：28

作者：

Woo, ER ^{[1
]}

Kim, HJ ^{[1
]}

Kwak, JH ^{[1
]}

Lim, YK ^{[1
]}

Park, SK ^{[1
]}

Kim, HS ^{[1
]}

Lee, CK ^{[1
]}

Park, H ^{[1
]}

机构：

[1] KOREA RES INST CHEM TECHNOL, PHARMACEUT SCREENING CTR, TAEJON 305606, SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1997年 / 20卷 / 01期

关键词：

antivirals; natural products; screening; herpes simplex virus type I; II; selective index (SI);

D O I：

10.1007/BF02974043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to find antiviral compounds against Herpes simplex virus type I (HSV-1) and II (HSV-2) from natural products, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. More than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. Among them, several medicinal plants showed potent anti-herpetic activity. Selective indexes (SI) of the EtOAc extract of Caraganae Radix (Caragana sinica) against HSV-1 and HSV-2 were more than 8.06 and 24.79, SI of the MeOH extract of Acer okamotoanum leaves were 3.92 and 3.51, SI of the CH2Cl2 extract of Veratri Rhizoma et Radix (Veratrum patulum) were 5.49 and 1.31 and SI of the MeOH extract of aerial part of Osmundae Rhizoma (Osmunda japonica) were more than 3.45 and 1.25, respectively.

引用

页码：58 / 67

页数：10

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