The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies

被引：14

作者：

Dandona, Sonny ^{[1
]}

Chen, Li ^{[1
]}

Fan, Meng ^{[1
]}

Alam, Md Afaque ^{[1
]}

Assogba, Olivia ^{[1
]}

Belanger, Melanie ^{[1
]}

Williams, Kathryn ^{[1
]}

Wells, George A. ^{[1
]}

Tang, W. H. Wilson ^{[2
]}

Ellis, Stephen G. ^{[2
]}

Hazen, Stanley L. ^{[2
]}

McPherson, Ruth ^{[1
]}

Roberts, Robert ^{[1
]}

Stewart, Alexandre F. R. ^{[1
]}

机构：

[1] Univ Ottawa, Inst Heart, John & Jennifer Ruddy Canadian Cardiovasc Genet C, Ottawa, ON, Canada

[2] Cleveland Clin Fdn, Cleveland, OH 44195 USA

来源：

HUMAN GENETICS | 2010年 / 127卷 / 01期

基金：

加拿大健康研究院; 美国国家卫生研究院; 加拿大创新基金会;

关键词：

LYMPHOTOXIN-ALPHA GENE; MYOCARDIAL-INFARCTION; FAMILIAL OCCURRENCE; RISK-FACTOR; TNFSF4; PCSK9;

D O I：

10.1007/s00439-009-0761-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The transcription factor GATA2 was reported to associate with coronary artery disease (CAD) in the family-based Genecard sample (Connelly et al. in PLoS Genet 2:e139, 2006). We asked whether GATA2 associates with sporadic cases of CAD in the Ottawa Heart Genomics Study (OHGS) and Cleveland Clinic (CC) populations. We genotyped the lead single nucleotide polymorphism (SNP) from Genecard, rs2713604 which is located in intron 5-6 of GATA2 in 600 CAD cases and 625 controls, as well as a tag SNP rs1573949 (r (2) = 0.87 in Caucasians of European ancestry in Utah from HapMap) in 1,136 cases and 1,162 controls in the OHGS1 population. A further 1,838 CAD cases and 913 controls derived from an independent sample combining genotypes from CC and OHGS2 populations were genotyped for rs1573949. Neither of the genotyped SNPs associates with CAD in the OHGS1 or CC/OHGS2 populations. Our data suggest that GATA2 does not contribute to the development of angiographic CAD among sporadic cases.

引用

页码：101 / 105

页数：5

共 19 条

[1]

Lymphotoxin-α gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study [J].

Clarke, Robert ;

Xu, Peng ;

Bennett, Derrick ;

Lewington, Sarah ;

Zondervan, Krina ;

Parish, Sarah ;

Palmer, Alison ;

Clark, Sarah ;

Cardon, Lon ;

Peto, Richard ;

Lathrop, Mark ;

Collins, Rory .

PLOS GENETICS, 2006, 2 (07) :990-996

[2]

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

[3]

GATA2 is associated with familial early-onset coronary artery disease [J].

Connelly, Jessica J. ;

Wang, Tianyuan ;

Cox, Julie E. ;

Haynes, Carol ;

Wang, Liyong ;

Shah, Svati H. ;

Crosslin, David R. ;

Hale, A. Brent ;

Nelson, Sarah ;

Crossman, David C. ;

Granger, Christopher B. ;

Haines, Jonathan L. ;

Jones, Christopher J. H. ;

Vance, Jeffery M. ;

Goldschmidt-Clermont, Pascal J. ;

Kraus, William E. ;

Hauser, Elizabeth R. ;

Gregory, Simon G. .

PLOS GENETICS, 2006, 2 (08) :1265-1273

[4]

A common variant on chromosome 9p21 affects the risk of myocardial infarction [J].

Helgadottir, Anna ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Gretarsdottir, Solveig ;

Blondal, Thorarinn ;

Jonasdottir, Aslaug ;

Jonasdottir, Adalbjorg ;

Sigurdsson, Asgeir ;

Baker, Adam ;

Palsson, Arnar ;

Masson, Gisli ;

Gudbjartsson, Daniel F. ;

Magnusson, Kristinn P. ;

Andersen, Karl ;

Levey, Allan I. ;

Backman, Valgerdur M. ;

Matthiasdottir, Sigurborg ;

Jonsdottir, Thorbjorg ;

Palsson, Stefan ;

Einarsdottir, Helga ;

Gunnarsdottir, Steinunn ;

Gylfason, Arnaldur ;

Vaccarino, Viola ;

Hooper, W. Craig ;

Reilly, Muredach P. ;

Granger, Christopher B. ;

Austin, Harland ;

Rader, Daniel J. ;

Shah, Svati H. ;

Quyyumi, Arshed A. ;

Gulcher, Jeffrey R. ;

Thorgeirsson, Gudmundur ;

Thorsteinsdottir, Unnur ;

Kong, Augustine ;

Stefansson, Kari .

SCIENCE, 2007, 316 (5830) :1491-1493

[5]

Validation Study of Genetic Associations with Coronary Artery Disease on Chromosome 3q13-21 and Potential Effect Modification by Smoking [J].

Horne, Benjamin D. ;

Hauser, Elizabeth R. ;

Wang, Liyong ;

Muhlestein, Joseph B. ;

Anderson, Jeffrey L. ;

Carlquist, John F. ;

Shah, Svati H. ;

Kraus, William E. .

ANNALS OF HUMAN GENETICS, 2009, 73 :551-558

[6]

A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction [J].

Kathiresan, Sekar .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (21) :2299-2300

[7]

Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population [J].

Koch, Werner ;

Hoppmann, Petra ;

Mueller, Jakob C. ;

Schoemig, Albert ;

Kastrati, Adnan .

NATURE GENETICS, 2008, 40 (12) :1386-1387

[8]

Heart Disease and Stroke Statistics-2009 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee [J].

Lloyd-Jones, Donald ;

Adams, Robert ;

Carnethon, Mercedes ;

De Simone, Giovanni ;

Ferguson, T. Bruce ;

Flegal, Katherine ;

Ford, Earl ;

Furie, Karen ;

Go, Alan ;

Greenlund, Kurt ;

Haase, Nancy ;

Hailpern, Susan ;

Ho, Michael ;

Howard, Virginia ;

Kissela, Brett ;

Kittner, Steven ;

Lackland, Daniel ;

Lisabeth, Lynda ;

Marelli, Ariane ;

McDermott, Mary ;

Meigs, James ;

Mozaffarian, Dariush ;

Nichol, Graham ;

O'Donnell, Christopher ;

Roger, Veronique ;

Rosamond, Wayne ;

Sacco, Ralph ;

Sorlie, Paul ;

Stafford, Randall ;

Steinberger, Julia ;

Thom, Thomas ;

Wasserthiel-Smoller, Sylvia ;

Wong, Nathan ;

Wylie-Rosett, Judith ;

Hong, Yuling .

CIRCULATION, 2009, 119 (03) :E21-E181

[9]

A common allele on chromosome 9 associated with coronary heart disease [J].

McPherson, Ruth ;

Pertsemlidis, Alexander ;

Kavaslar, Nihan ;

Stewart, Alexandre F. R. ;

Roberts, Robert ;

Cox, David R. ;

Hinds, David A. ;

Pennacchio, Len A. ;

Tybjaerg-Hansen, Anne ;

Folsom, Aaron R. ;

Boerwinkle, Eric ;

Hobbs, Helen H. ;

Cohen, Jonathan C. .

SCIENCE, 2007, 316 (5830) :1488-1491

[10]

Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults [J].

Murabito, JM ;

Pencina, MJ ;

Nam, BH ;

D'Agostino, RB ;

Wang, TJ ;

Lloyd-Jones, D ;

Wilson, PWF ;

O'Donnell, CJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (24) :3117-3123

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