Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability

被引：109

作者：

Baum, Larry ^{[1
]}

Chan, Iris Hiu Shuen ^{[2
]}

Cheung, Stanley Kwok-Kuen ^{[3
]}

Goggins, William B. ^{[4
]}

Mok, Vincent ^{[3
]}

Lam, Linda ^{[5
]}

Leung, Vivian ^{[5
]}

Hui, Elsie ^{[3
]}

Ng, Chelsia ^{[3
]}

Woo, Jean ^{[3
]}

Chiu, Helen Fung Kum ^{[5
]}

Zee, Benny Chung-Ying ^{[6
]}

Cheng, William ^{[7
]}

Chan, Ming-Houng ^{[8
]}

Szeto, Samuel ^{[8
]}

Lui, Victor ^{[5
]}

Tsoh, Joshua ^{[5
]}

Bush, Ashley I. ^{[9
,10
,11
]}

Lam, Christopher Wai Kei ^{[2
]}

Kwok, Timothy ^{[3
]}

机构：

[1] Chinese Univ Hong Kong, Sch Pharm, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Sch Publ Hlth, Shatin, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China

[6] Chinese Univ Hong Kong, Ctr Clin Trials, Shatin, Hong Kong, Peoples R China

[7] Chinese Univ Hong Kong, Inst Chinese Med, Clin Trials Sect, Shatin, Hong Kong, Peoples R China

[8] Kwong Wah Hosp, Dept Med & Geriatr, Kowloon, Hong Kong, Peoples R China

[9] Univ Melbourne, Mental Hlth Res Inst Victoria, Oxidat Disorders Lab, Parkville, Vic 3052, Australia

[10] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

[11] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Genet & Aging Res Unit, Charlestown, MA 02129 USA

来源：

BIOMETALS | 2010年 / 23卷 / 01期

关键词：

Alzheimer's disease; Aluminum; Arsenic; Metals; MMSE; Serum; Zinc; AGE-AT-ONSET; TRACE-ELEMENTS; ALUMINUM; COPPER; IRON; IMBALANCES; ABSORPTION; RISK; FISH;

D O I：

10.1007/s10534-009-9277-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc, copper, and iron aggregate A beta and accumulate in Alzheimer's disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 mu mol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p < 0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD.

引用

页码：173 / 179

页数：7

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