uPA, uPAR, PAI-I: key intersection of proteolytic, adhesive and chemotactic highways?

被引：224

作者：

Blasi, F

机构：

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(97)01121-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Through multiple interaction, the urokinase plasminogen activator (uPA) system forms a self-regulated, surface-located, functionally important chemokine. This article examines new data in the field.

引用

页码：415 / 417

页数：3

共 24 条

[1]

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes [J].

Bianchi, E ;

Ferrero, E ;

Fazioli, F ;

Mangili, F ;

Wang, J ;

Bender, JR ;

Blasi, F ;

Pardi, R .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (05) :1133-1141

[2]

UROKINASE-TYPE PLASMINOGEN-ACTIVATOR - PROENZYME, RECEPTOR, AND INHIBITORS [J].

BLASI, F ;

VASSALLI, JD ;

DANO, K .

JOURNAL OF CELL BIOLOGY, 1987, 104 (04) :801-804

[3]

INDUCTION OF CELL-MIGRATION BY PROUROKINASE BINDING TO ITS RECEPTOR - POSSIBLE MECHANISM FOR SIGNAL-TRANSDUCTION IN HUMAN EPITHELIAL-CELLS [J].

BUSSO, N ;

MASUR, SK ;

LAZEGA, D ;

WAXMAN, S ;

OSSOWSKI, L .

JOURNAL OF CELL BIOLOGY, 1994, 126 (01) :259-270

[4]

ALPHA-(2)-MACROGLOBULIN RECEPTOR LDL-RECEPTOR-RELATED-PROTEIN (LRP)-DEPENDENT INTERNALIZATION OF THE UROKINASE RECEPTOR [J].

CONESE, M ;

NYKJAER, A ;

PETERSEN, CM ;

CREMONA, O ;

PARDI, R ;

ANDREASEN, PA ;

GLIEMANN, J ;

CHRISTENSEN, EI ;

BLASI, F .

JOURNAL OF CELL BIOLOGY, 1995, 131 (06) :1609-1622

[5]

RECEPTOR-MEDIATED INTERNALIZATION AND DEGRADATION OF UROKINASE IS CAUSED BY ITS SPECIFIC INHIBITOR PAI-1 [J].

CUBELLIS, MV ;

WUN, TC ;

BLASI, F .

EMBO JOURNAL, 1990, 9 (04) :1079-1085

[6]

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? [J].

Deng, G ;

Curriden, SA ;

Wang, SJ ;

Rosenberg, S ;

Loskutoff, DJ .

JOURNAL OF CELL BIOLOGY, 1996, 134 (06) :1563-1571

[7]

Phosphorylation of human pro-urokinase on Ser(138/303) impairs its receptor-dependent ability to promote myelomonocytic adherence and motility [J].

Franco, P ;

Iaccarino, C ;

Chiaradonna, F ;

Brandazza, A ;

Iavarone, C ;

Mastronicola, MR ;

Nolli, ML ;

Stoppelli, MP .

JOURNAL OF CELL BIOLOGY, 1997, 137 (03) :779-791

[8]

GrondahlHansen J, 1995, CLIN CANCER RES, V1, P1079

[9]

Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans - A murine transgenic model [J].

Gyetko, MR ;

Chen, GH ;

McDonald, RA ;

Goodman, R ;

Huffnagle, GB ;

Wilkinson, CC ;

Fuller, JA ;

Toews, GB .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (08) :1818-1826

[10]

Cell-surface acceleration of urokinase-catalyzed receptor cleavage [J].

HoyerHansen, G ;

Ploug, M ;

Behrendt, N ;

Ronne, E ;

Dano, K .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 243 (1-2) :21-26

← 1 2 3 →