Inhibition by L-NA, a nitric oxide synthase inhibitor, of naloxone-precipitated withdrawal signs in a mouse model of cholestasis

被引：16

作者：

Ghafourifar, P ^{[1
]}

Dehpour, AR ^{[1
]}

Akbarloo, N ^{[1
]}

机构：

[1] UNIV TEHRAN MED SCI, SCH MED, DEPT PHARMACOL, TEHRAN, IRAN

来源：

LIFE SCIENCES | 1997年 / 60卷 / 19期

关键词：

cholestasis; nitric oxide; bile duct; opioids; naloxone; withdrawal signs;

D O I：

10.1016/S0024-3205(97)00115-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Following the naloxone administration in bile duct resected animals, striking opioid withdrawal signs are observed due to increased opioidergic tone. Pretreatment of animals with L-nitro arginine, a nitric oxide synthase inhibitor, reduces the naloxone-precipitated withdrawal signs as well as increase the antinociception. The results of this study support evidence for the involvement of the L-arg-nitric oxide pathway in opioidergic-dependent manifestation of cholestasis in an animal model.

引用

页码：PL265 / PL270

页数：6

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