Characterizing tissue stiffness at the tip of a rigid needle using an opto-mechanical force sensor

被引:32
作者
Beekmans, S. V. [1 ,2 ]
Iannuzzi, D. [1 ,2 ]
机构
[1] Vrije Univ Amsterdam, Deparment Phys & Astron, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, LaserLab Amsterdam, Amsterdam, Netherlands
基金
欧洲研究理事会;
关键词
Ferrule-top technology; In situ indentation; Remote actuation; Interferometry; Tissue Stiffness; Micromechanics; Minimally invasive instrument; SOFT BIOLOGICAL TISSUES; ELASTIC-MODULUS; BREAST-CANCER; MICROSCOPY; INDENTATION; OSTEOARTHRITIS; ELASTOGRAPHY; BIOMECHANICS; CARTILAGE; HARDNESS;
D O I
10.1007/s10544-016-0039-1
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
We present a novel device that allows the user to measure the Young Modulus of a material at the opening of a 5 mm diameter needle. The device relies on a miniaturized cantilever spring mounted at the end of the needle and interrogated via Fabry-Perot optical fiber interferometry. The probe is repetitively brought in and out of contact with the sample at the end of the needle by means of a steel cable that is controlled via a piezoelectric actuator located at the proximal end. We demonstrate the ability of our device to detect and quantify layers of varying stiffness during needle insertion in a gelatin phantom and to successfully locate tissue boundaries in bovine liver tissue embedded in gelatin.
引用
收藏
页码:1 / 8
页数:8
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