G-protein-coupled receptors (GPCRs) mediate a diverse array of biological functions as a result of their ability to respond selectively to extra cellular stimuli, which ultimately results in cell-specific activation of signaling cascades. Generally, GPCR activation is followed rapidly by a loss of responsiveness, termed desensitization, which is then followed by a period of recovery or resensitization, These changes in signaling potential are tightly regulated, primarily via mechanisms that involve GPCR phosphorylation and trafficking to distinct locations within the cell. Tagging of GPCRs with the green fluorescent protein (GFP) has enabled the direct visualization of real-time trafficking of GPCRs in living cells. Such analyses have provided crucial insight into the mechanisms involved in controlling GPCR function.
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Awaji, T
Hirasawa, A
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Hirasawa, A
Kataoka, M
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Kataoka, M
Shinoura, H
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Shinoura, H
Nakayama, Y
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Nakayama, Y
Sugawara, T
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Sugawara, T
Izumi, S
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Izumi, S
Tsujimoto, G
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Barlic, J
Khandaker, MH
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Khandaker, MH
Mahon, E
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Mahon, E
Andrews, J
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Andrews, J
DeVries, ME
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
DeVries, ME
Mitchell, GB
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Mitchell, GB
Rahimpour, R
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Rahimpour, R
Tan, CM
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Tan, CM
Ferguson, SSG
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Ferguson, SSG
Kelvin, DJ
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John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, CanadaJohn P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
机构:
Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Awaji, T
Hirasawa, A
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Hirasawa, A
Kataoka, M
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Kataoka, M
Shinoura, H
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Shinoura, H
Nakayama, Y
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Nakayama, Y
Sugawara, T
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Sugawara, T
Izumi, S
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
Izumi, S
Tsujimoto, G
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Natl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, JapanNatl Childrens Med Res Ctr, Dept Mol & Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Barlic, J
Khandaker, MH
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h-index: 0
机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Khandaker, MH
Mahon, E
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Mahon, E
Andrews, J
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Andrews, J
DeVries, ME
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
DeVries, ME
Mitchell, GB
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Mitchell, GB
Rahimpour, R
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Rahimpour, R
Tan, CM
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Tan, CM
Ferguson, SSG
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机构:John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada
Ferguson, SSG
Kelvin, DJ
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机构:
John P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, CanadaJohn P Robarts Res Inst, Lab Mol Immunol & Inflammat, London, ON N6G 2V4, Canada