Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

被引：69

作者：

Bakker, Marije F. ^{[1
]}

Peeters, Petra H. M. ^{[1
,3
]}

Klaasen, Veronique M. ^{[1
,4
]}

Bueno-de-Mesquita, H. Bas ^{[2
,3
,5
,6
]}

Jansen, Eugene H. J. M. ^{[5
]}

Ros, Martine M. ^{[5
]}

Travier, Noemie ^{[7
]}

Olsen, Anja ^{[8
]}

Tjonneland, Anne ^{[8
]}

Overvad, Kim ^{[9
]}

Rinaldi, Sabina ^{[10
]}

Romieu, Isabelle ^{[10
]}

Brennan, Paul ^{[10
]}

Boutron-Ruault, Marie-Christine ^{[11
,12
,13
]}

Perquier, Florence ^{[11
,12
,13
]}

Cadeau, Claire ^{[11
,12
,13
]}

Boeing, Heiner ^{[14
]}

Aleksandrova, Krasimira ^{[14
]}

Kaaks, Rudolf ^{[15
]}

Kuehn, Tilman ^{[15
]}

Trichopoulou, Antonia ^{[16
,17
]}

Lagiou, Pagona ^{[16
,18
]}

Trichopoulos, Dimitrios ^{[17
,18
,19
]}

Vineis, Paolo ^{[3
,20
]}

Krogh, Vittorio ^{[21
]}

Panico, Salvatore ^{[22
]}

Masala, Giovanna ^{[23
]}

Tumino, Rosario ^{[24
,25
]}

Weiderpass, Elisabete ^{[26
,27
,28
,29
]}

Skeie, Guri ^{[26
]}

Lund, Eiliv ^{[26
]}

Ramon Quiros, J. ^{[30
]}

Ardanaz, Eva ^{[31
,32
]}

Navarro, Carmen ^{[33
,34
,35
]}

Amiano, Pilar ^{[33
,36
]}

Sanchez, Maria-Jose ^{[33
,37
]}

Buckland, Genevieve ^{[7
]}

Ericson, Ulrika ^{[38
]}

Sonestedt, Emily ^{[38
]}

Johansson, Matthias ^{[10
,39
]}

Sund, Malin ^{[40
]}

Travis, Ruth C. ^{[41
]}

Key, Timothy J. ^{[41
]}

Khaw, Kay-Tee ^{[42
]}

Wareham, Nick ^{[43
]}

Riboli, Elio ^{[3
]}

van Gils, Carla H. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[4] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[5] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[6] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[7] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain

[8] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[9] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[10] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France

[11] INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, Nutr Hormones & Womens Hlth Team, Villejuif, France

[12] Univ Paris Sud, UMRS 1018, Villejuif, France

[13] IGR, Villejuif, France

[14] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[15] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[16] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[17] Hellen Hlth Fdn, Athens, Greece

[18] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, 665 Huntington Ave, Boston, MA 02115 USA

[19] Acad Athens, Bur Epidemiol Res, Athens, Greece

[20] Human Genet Fdn HuGeF, Turin, Italy

[21] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[22] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[23] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[24] Civ MP Arezzo Hosp, Canc Registry, Asp Ragusa, Italy

[25] Civ MP Arezzo Hosp, Histopathol Unit, Asp Ragusa, Italy

[26] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[27] Canc Registry Norway, Dept Res, Inst Populat Based Canc Res, Oslo, Norway

[28] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[29] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[30] Publ Hlth Directorate, Asturias, Spain

[31] Navarre Publ Hlth Inst, Pamplona, Spain

[32] CIBER Epidemiol & Publ Hlth CIPERESP, Madrid, Spain

[33] CIBER Epidemiol & Salud Publ, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain

[34] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[35] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[36] Hlth Dept Basque Reg, BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[37] Andalusian Sch Publ Hlth, Granada, Spain

[38] Lund Univ, Dept Clin Sci, Malmo, Sweden

[39] Dept Biobank Res, Umea, Sweden

[40] Umea Univ, Dept Surg, Umea, Sweden

[41] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[42] Univ Cambridge, Cambridge, England

[43] Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2016年 / 103卷 / 02期

基金：

英国医学研究理事会; 欧洲研究理事会; 英国惠康基金;

关键词：

breast cancer; EPIC; antioxidants; carotenoids; plasma; ESTROGEN-RECEPTOR; ALPHA-TOCOPHEROL; SERUM CAROTENOIDS; VEGETABLE INTAKE; POOLED ANALYSIS; BETA-CAROTENE; FRUIT; ANTIOXIDANTS; METAANALYSIS; VALIDITY;

D O I：

10.3945/ajcn.114.101659

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and 454 vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. Results: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). Conclusion: Our results indicate that higher concentrations of plasma beta-carotene and alpha-carotene are associated with lower breast cancer risk of ER tumors.

引用

页码：454 / 464

页数：11

共 45 条

[1]

Plasma carotenoids as biomarkers of intake of fruits and vegetables:: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC) [J].

Al-Delaimy, WK ;

Ferrari, P ;

Slimani, N ;

Pala, V ;

Johansson, I ;

Nilsson, S ;

Mattisson, I ;

Wirfalt, E ;

Galasso, R ;

Palli, D ;

Vineis, P ;

Tumino, R ;

Dorronsoro, M ;

Pera, G ;

Ocké, MC ;

Bueno-de-Mesquita, HB ;

Overvad, K ;

Chirlaque, MAD ;

Trichopoulou, A ;

Naska, A ;

Tjonneland, A ;

Olsen, A ;

Lund, E ;

Alsaker, EHR ;

Barricarte, A ;

Kesse, E ;

Boutron-Ruault, MC ;

Clavel-Chapelon, F ;

Key, TJ ;

Spencer, E ;

Bingham, S ;

Welch, AA ;

Sanchez-Perez, MJ ;

Nagel, G ;

Linseisen, J ;

Quirós, JR ;

Peeters, PHM ;

van Gils, CH ;

Boeing, H ;

van Kappel, AL ;

Steghens, JP ;

Riboli, E .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2005, 59 (12) :1387-1396

[2]

Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies [J].

Aune, D. ;

Chan, D. S. M. ;

Vieira, A. R. ;

Rosenblatt, D. A. Navarro ;

Vieira, R. ;

Greenwood, D. C. ;

Norat, T. .

BREAST CANCER RESEARCH AND TREATMENT, 2012, 134 (02) :479-493

[3]

Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies [J].

Aune, Dagfinn ;

Chan, Doris S. M. ;

Vieira, Ana Rita ;

Rosenblatt, Deborah A. Navarro ;

Vieira, Rui ;

Greenwood, Darren C. ;

Norat, Teresa .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (02) :356-373

[4]

Dietary patterns and risk of breast cancer [J].

Baglietto, L. ;

Krishnan, K. ;

Severi, G. ;

Hodge, A. ;

Brinkman, M. ;

English, D. R. ;

McLean, C. ;

Hopper, J. L. ;

Giles, G. G. .

BRITISH JOURNAL OF CANCER, 2011, 104 (03) :524-531

[5]

Which plasma antioxidants are most related to fruit and vegetable consumption? [J].

Block, G ;

Norkus, E ;

Hudes, M ;

Mandel, S ;

Helzlsouer, K .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 154 (12) :1113-1118

[6]

Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Women's Health Study [J].

Boggs, Deborah A. ;

Palmer, Julie R. ;

Wise, Lauren A. ;

Spiegelman, Donna ;

Stampfer, Meir J. ;

Adams-Campbell, Lucile L. ;

Rosenberg, Lynn .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (11) :1268-1279

[7]

DNA damage, DNA repair, and alcohol toxicity - A review [J].

Brooks, PJ .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1997, 21 (06) :1073-1082

[8]

Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study [J].

Buckland, G. ;

Travier, N. ;

Cottet, V. ;

Gonzalez, C. A. ;

Lujan-Barroso, L. ;

Agudo, A. ;

Trichopoulou, A. ;

Lagiou, P. ;

Trichopoulos, D. ;

Peeters, P. H. ;

May, A. ;

Bueno-de-Mesquita, H. B. ;

Duijnhoven, F. J. Bvan ;

Key, T. J. ;

Allen, N. ;

Khaw, K. T. ;

Wareham, N. ;

Romieu, I. ;

McCormack, V. ;

Boutron-Ruault, M. ;

Clavel-Chapelon, F. ;

Panico, S. ;

Agnoli, C. ;

Palli, D. ;

Tumino, R. ;

Vineis, P. ;

Amiano, P. ;

Barricarte, A. ;

Rodriguez, L. ;

Sanchez, M. J. ;

Chirlaque, M. D. ;

Kaaks, R. ;

Teucher, B. ;

Boeing, H. ;

Bergmann, M. M. ;

Overvad, K. ;

Dahm, C. C. ;

Tjonneland, A. ;

Olsen, A. ;

Manjer, J. ;

Wirfalt, E. ;

Hallmans, G. ;

Johansson, I. ;

Lund, E. ;

Hjartaker, A. ;

Skeie, G. ;

Vergnaud, A. C. ;

Norat, T. ;

Romaguera, D. ;

Riboli, E. .

INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (12) :2918-2927

[9]

COMSTOCK GW, 1993, CLIN CHEM, V39, P1075

[10]

Relationships of serum carotenoids, retinol, α-tocopherol, and selenium with breast cancer risk:: results from a prospective study in Columbia, Missouri (United States) [J].

Dorgan, JF ;

Sowell, A ;

Swanson, CA ;

Potischman, N ;

Miller, R ;

Schussler, N ;

Stephenson, HE .

CANCER CAUSES & CONTROL, 1998, 9 (01) :89-97

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