Chemoenzymatic synthesis of GM(3), Lewis x and sialyl Lewis x oligosaccharides in C-13-enriched form

被引：36

作者：

Probert, MA

Milton, MJ

Harris, R

Schenkman, S

Brown, JM

Homans, SW

Field, RA

机构：

[1] UNIV ST ANDREWS,SCH CHEM,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

[2] UNIV ST ANDREWS,CTR BIOMOL SCI,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

[3] UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT MICROBIOL IMUNOL & PARASITOL,BR-04023062 SAO PAULO,BRAZIL

[4] MARTEK BIOSCI CORP,COLUMBIA,MD 21045

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0040-4039(97)01304-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In connection with studies on the solution and protein-bound conformation of oligosaccharides, we had reason to consider the application of C-13-enriched sugars. Herein we describe the synthesis of ganglioside GM(3) trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3) from [U-C-13]-D-Glc, [U-C-13]-L-Gal and [U-C-13]-pyruvate. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：5861 / 5864

页数：4

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