The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility

被引：74

作者：

Bottazzi, Barbara

Bastone, Antonio

Doni, Andrea

Garlanda, Cecilia

Valentino, Sonia

Deban, Livija

Maina, Virginia

Cotena, Alessia

Moalli, Federica

Vago, Luca

Salustri, Antonietta

Romani, Luigina

Mantovani, Alberto

机构：

[1] Ist Clin Humanitas, I-20089 Milan, Italy

[2] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy

[3] Univ Milan, Ctr IDET, Inst Gen Pathol, Milan, Italy

[4] L Sacco Hosp Vialba, Milan, Italy

[5] Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, Rome, Italy

[6] Univ Perugia, Dept Expt Med & Biochem Sci, Microbiol Sect, I-06100 Perugia, Italy

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2006年 / 79卷 / 05期

关键词：

acute-phase protein; extracellular matrix; acute myocardial infarction;

D O I：

10.1189/jlb.1005557

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. PTX3 is highly conserved in evolution and is produced by innate-immunity cells in response to proinflammatory signals and Toll-like receptor engagement. PTX3 plays complex, nonredundant functions in vivo, acting as a predecessor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, and hence, playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility.

引用

页码：909 / 912

页数：4

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