CD34: To select or not to select? That is the question

被引：39

作者：

Dao, MA ^{[1
]}

Nolta, JA ^{[1
]}

机构：

[1] Univ So Calif, Childrens Hosp Los Angeles, Sch Med,Dept Pediat, Div Res Immunol Bone Marrow Transplantat, Los Angeles, CA 90027 USA

来源：

LEUKEMIA | 2000年 / 14卷 / 05期

关键词：

CD34; hematopoietic stem cells; transplantation;

D O I：

10.1038/sj.leu.2401781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34(+) cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

引用

页码：773 / 776

页数：4

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