5-Hydroxy-6-methyluracil, an Efficient Scavenger of Peroxyl Radical in Water

被引：13

作者：

Grabovskiy, S. A. ^{[1
]}

Abdrakhmanova, A. R. ^{[1
]}

Murinov, Y. I. ^{[1
]}

Kabal'nova, N. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Res Ctr, Ufa 450054, Russia

来源：

CURRENT ORGANIC CHEMISTRY | 2009年 / 13卷 / 17期

关键词：

RATE CONSTANTS; OXIDATION; DNA; DAMAGE; ANTIOXIDANTS; PEROXIDATION; FLAVONOIDS;

D O I：

10.2174/138527209789578081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2'-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 +/- 0.04 at 54.6 degrees C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26 degrees-84 degrees C.

引用

页码：1733 / 1736

页数：4

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