Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation

被引：129

作者：

Tan, KL

Bergman, RG ^{[1
]}

Ellman, JA

机构：

[1] Univ Calif Berkeley, Dept Chem, Ctr New Direct Organ Synth, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Lab, Div Chem Sci, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 47期

关键词：

D O I：

10.1021/ja0281129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This reports first intermolecular coupling of unactivated alkenes, including isomerizable alkenes, to a range of heterocycles using a Rh(I) catalyst. A variety of functional groups were incorporated, including esters, nitriles, and acetals. The intermolecular coupling became possible after it was discovered that weak acids dramatically increase the rate of both the inter- and intramolecular reactions. Copyright © 2002 American Chemical Society.

引用

页码：13964 / 13965

页数：2

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