Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures

被引：14

作者：

Chou, IC

Tsai, CH

Lee, CC

Lin, SS

Tsai, FJ ^{[1
]}

机构：

[1] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan

[2] Taichung Healthcare & Management Univ, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[4] China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan

[5] China Med Univ, Coll Chinese Med, Taichung, Taiwan

来源：

EPILEPSY RESEARCH | 2004年 / 60卷 / 01期

关键词：

brain-derived neurotrophic factor; polymorphism; BDNF; febrile seizures;

D O I：

10.1016/j.eplepsyres.2004.05.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various studies have shown that brain-derived neurotrophic factor (BDNF) increased neuronal excitability. We tested that BDNF might be involved in the etiology of febrile seizures (FSs). A total of 186 Taiwanese children were divided into two groups: (1) FSs (n = 104); (2) normal control subjects (n = 83). A single base pair polymorphism SNP6265 (Val66Met) at position 196 was analyzed. Our findings suggest that the BDNF polymorphisms were not candidate genetic markers. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：27 / 29

页数：3

共 8 条

[1] BDNF and epilepsy: too much of a good thing? [J].