Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

被引：27

作者：

Caillaud, A. ^{[1
]}

de la Iglesia, P. ^{[1
]}

Campas, M. ^{[1
]}

Elandaloussi, L. ^{[1
]}

Fernandez, M. ^{[1
]}

Mohammad-Noor, N. ^{[2
]}

Andree, K. ^{[1
]}

Diogene, J. ^{[1
]}

机构：

[1] IRTA, San Carlos de la Rapita 43540, Spain

[2] Univ Malaysia Sabah, Borneo Marine Res Inst, Kota Kinabalu 88999, Sabah, Malaysia

来源：

TOXICON | 2010年 / 55卷 / 2-3期

关键词：

Prorocentrum rhathymum; Protein phosphatase; inhibition assay; Neuroblastoma; cell-based assay; LC-MS/MS; Okadaic acid; INHIBITION ASSAY; SEQUENCES; TOXINS;

D O I：

10.1016/j.toxicon.2009.07.016

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：633 / 637

页数：5

共 16 条

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Potentially toxic epiphytic Prorocentrum (Dinophyceae) species in Greek coastal waters [J].