Vulnerability genes or plasticity genes?

被引:718
作者
Belsky, J. [1 ]
Jonassaint, C. [2 ]
Pluess, M. [1 ]
Stanton, M. [2 ]
Brummett, B. [3 ]
Williams, R. [3 ]
机构
[1] Birkbeck Univ London, Inst Study Children Families & Social Issues, London WC1B 3RA, England
[2] Duke Univ, Dept Psychol, Durham, NC 27706 USA
[3] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA
关键词
genetics; environment (G x E); parenting; life events; STRESSFUL LIFE EVENTS; OXIDASE-A GENOTYPE; SEROTONIN TRANSPORTER; DIFFERENTIAL SUSCEPTIBILITY; ENVIRONMENT INTERACTION; EXTERNALIZING BEHAVIOR; 5-HTTLPR POLYMORPHISM; PARENTING QUALITY; RECEPTOR DRD4; RISK;
D O I
10.1038/mp.2009.44
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to adversity because of their genetic make up as simultaneously most likely to benefit from supportive or enriching experiences-or even just the absence of adversity. Recent G x E findings consistent with this perspective and involving monoamine oxidase-A, 5-HTTLPR (5-hydroxytryptamine-linked polymorphic region polymorphism) and dopamine receptor D4 (DRD4) are reviewed for illustrative purposes. Results considered suggest that putative 'vulnerability genes' or 'risk alleles' might, at times, be more appropriately conceptualized as 'plasticity genes', because they seem to make individuals more susceptible to environmental influences-for better and for worse. Molecular Psychiatry (2009) 14, 746-754; doi:10.1038/mp.2009.44; published online 19 May 2009
引用
收藏
页码:746 / 754
页数:9
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