Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis

被引：13

作者：

Julia, Eva

Montalban, Xavier

Al-zayat, Hanimad

Issazadeh-Navikas, Shohreh

Goertsches, Robert

Martin, Roland

Comabella, Manuel

机构：

[1] Univ Autonoma Barcelona, Unitat Neuroimmunol Clin, Hosp Gen Valle Hebron, Barcelona 08035, Spain

[2] Lund Univ, Dept Expt Med Sci, Sect Med Inflammat Res, Lund, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 180卷 / 1-2期

关键词：

T cells; apoptosis; multiple sclerosis;

D O I：

10.1016/j.jneuroim.2006.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：147 / 158

页数：12

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