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Neuroprotective effects of estrogens following ischemic stroke

被引：193
作者：
Suzuki, Shotaro
Brown, Candice M.
Wise, Phyllis M. [1 ]
机构：
[1] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2009年 / 30卷 / 02期
基金：
美国国家卫生研究院;
关键词：
17; beta-Estradiol; Estrogen receptor; Estrogen therapy; Ischemia; Middle cerebral artery occlusion; Inflammation; Neurogenesis; Stroke; Women's health initiative; NITRIC-OXIDE SYNTHASE; CEREBRAL BLOOD-VESSELS; ADULT HIPPOCAMPAL NEUROGENESIS; HORMONE REPLACEMENT THERAPY; CORTICAL EXPLANT CULTURES; CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; RECEPTOR-ALPHA; BRAIN-INJURY; SUBVENTRICULAR ZONE;
D O I：
10.1016/j.yfrne.2009.04.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Our laboratory has investigated whether and how 17 beta-estradiol (E-2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E-2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E-2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations. Published by Elsevier Inc.
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页码：201 / 211
页数：11
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