Modified γ-cyclodextrins and their rocuronium complexes

被引：27

作者：

Cameron, KS ^{[1
]}

Clark, JK

Cooper, A

Fielding, L

Palin, R

Rutherford, SJ

Zhang, MQ

机构：

[1] Organon Res Labs Ltd, Dept Med & Analyt Chem, Newhouse ML1 5SH, Scotland

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 20期

关键词：

D O I：

10.1021/ol020126w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A series of per-6-substituted cyclodextrin derivatives was synthesized as synthetic host molecules for rocuronium, a steroidal muscle relaxant. By forming host-guest complexes with rocuronium, these cyclodextrin derivatives reverse the muscle relaxation induced by rocuronium in vitro and in vivo. The isothermal microcalorimetry data are consistent with the biological data supporting the encapsulation mechanism of action. Binary and biphasic complexes are reported with NMR experiments clearly showing free and bound rocuronium.

引用

页码：3403 / 3406

页数：4

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