Synthesis of 4-([F-18]fluoromethyl)phenyl isothiocyanate and its use in labelling oligonucleotides

被引：39

作者：

Hedberg, E

Langstrom, B

机构：

[1] UNIV UPPSALA,INST CHEM,DEPT ORGAN CHEM,S-75121 UPPSALA,SWEDEN

[2] UNIV UPPSALA,PET CTR,UAS,S-75185 UPPSALA,SWEDEN

来源：

ACTA CHEMICA SCANDINAVICA | 1997年 / 51卷 / 12期

关键词：

D O I：

10.3891/acta.chem.scand.51-1236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

4-([F-18] Fluoromethyl)phenyl isothiocyanate 8 was obtained from [F-18]fluoride and 4-(4-toluenesulfonyloxymethyl)phenyl isothiocyanate 5 in 13-15% isolated, decay-corrected radiochemical yield within 40 min from the end of cyclotron bombardment. The precursor 8 was used to label the oligonucleotide 5'-GCT,AAG,CGA,TGC,CTC, CGT-3', modified in the 5'-position with a hexylamine linker, in the 5'-position in up to 8% radiochemical yield.

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页码：1236 / 1240

页数：5

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