Eukaryotic translation initiation: there are (at least) two sides to every story

被引：110

作者：

Sachs, AB

Varani, G

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / 05期

关键词：

D O I：

10.1038/75120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eukaryotic cap and poly(A) tail binding proteins, elF4E and Pab1p play important roles in the initiation of protein synthesis. The recent structures of the complex of elF4E bound to the methylated guanosine (cap) found at the 5'end of messenger RNA (mRNA). the complex of elF4E bound to peptide fragments of two related translation factors (elF4G and 4E-BP1). and the complex of the N-terminal fragment of Pab1p bound to polyadenylate RNA have revealed that elF4E and Pab1p contain at least two distinct functional surfaces. One surface is used for binding mRNA, and the other for binding proteins involved in translation initiation.

引用

收藏

页码：356 / 361

页数：6

相关论文

共 50 条

[1] MESSENGER-RNA POLYADENYLATE-BINDING PROTEIN - GENE ISOLATION AND SEQUENCING AND IDENTIFICATION OF A RIBONUCLEOPROTEIN CONSENSUS SEQUENCE [J].

ADAM, SA ;

NAKAGAWA, T ;

SWANSON, MS ;

WOODRUFF, TK ;

DREYFUSS, G .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (08) :2932-2943

[2] Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation [J].

Allain, FHT ;

Gubser, CC ;

Howe, PWA ;

Nagai, K ;

Neuhaus, D ;

Varani, G .

NATURE, 1996, 380 (6575) :646-650

[3] ALTERED MESSENGER-RNA CAP RECOGNITION ACTIVITY OF INITIATION FACTOR-4E IN THE YEAST-CELL CYCLE DIVISION MUTANT CDC33 [J].

ALTMANN, M ;

TRACHSEL, H .

NUCLEIC ACIDS RESEARCH, 1989, 17 (15) :5923-5931

[4] THE MULTIPLE RNA-BINDING DOMAINS OF THE MESSENGER-RNA POLY(A)-BINDING PROTEIN HAVE DIFFERENT RNA-BINDING ACTIVITIES [J].

BURD, CG ;

MATUNIS, EL ;

DREYFUSS, G .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (07) :3419-3424

[5] Differential effects of aromatic and charged residue substitutions in the RNA binding domains of the yeast poly(A) binding protein [J].

Deardorff, JA ;

Sachs, AB .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 269 (01) :67-81

[6] Recognition of polyadenylate RNA by the poly(A)-binding protein [J].

Deo, RC ;

Bonanno, JB ;

Sonenberg, N ;

Burley, SK .

CELL, 1999, 98 (06) :835-845

[7] Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA [J].

Ding, JZ ;

Hayashi, MK ;

Zhang, Y ;

Manche, L ;

Krainer, AR ;

Xu, RM .

GENES & DEVELOPMENT, 1999, 13 (09) :1102-1115

[8] Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae [J].

Dominguez, D ;

Altmann, M ;

Benz, J ;

Baumann, U ;

Trachsel, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (38) :26720-26726

[9]

Feigenblum D, 1996, MOL CELL BIOL, V16, P5450

[10] 4E binding proteins inhibit the translation factor eIF4E without folded structure [J].

Fletcher, CM ;

McGuire, AM ;

Gingras, AC ;

Li, HJ ;

Matsuo, H ;

Sonenberg, N ;

Wagner, G .

BIOCHEMISTRY, 1998, 37 (01) :9-15

← 1 2 3 4 5 →