Drosophila p53: meeting the Grim Reaper

被引:16
作者
Steller, H [1 ]
机构
[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
关键词
D O I
10.1038/35014093
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The recent discovery of a Drosophila orthologue of the p53 tumour suppressor promises new insights into the complex function, regulation and evolution of one of the most intensely studied human disease proteins.
引用
收藏
页码:E100 / E102
页数:3
相关论文
共 15 条
[1]   Drosophila p53 binds a damage response element at the reaper locus [J].
Brodsky, MH ;
Nordstrom, W ;
Tsang, G ;
Kwan, E ;
Rubin, GM ;
Abrams, JM .
CELL, 2000, 101 (01) :103-113
[2]  
Brodsky MH, 2000, GENE DEV, V14, P666
[3]   Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function [J].
Goyal, L ;
McCall, K ;
Agapite, J ;
Hartwieg, E ;
Steller, H .
EMBO JOURNAL, 2000, 19 (04) :589-597
[4]   THE MEI-41 GENE OF DROSOPHILA-MELANOGASTER IS A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE HUMAN ATAXIA-TELANGIECTASIA GENE [J].
HARI, KL ;
SANTERRE, A ;
SEKELSKY, JJ ;
MCKIM, KS ;
BOYD, JB ;
HAWLEY, RS .
CELL, 1995, 82 (05) :815-821
[5]   A cloning method to identify caspases and their regulators in yeast:: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1 [J].
Hawkins, CJ ;
Wang, SL ;
Hay, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :2885-2890
[6]   The p53 gene family [J].
Kaelin, WG .
ONCOGENE, 1999, 18 (53) :7701-7705
[7]   Twenty years of p53 research: structural and functional aspects of the p53 protein [J].
May, P ;
May, E .
ONCOGENE, 1999, 18 (53) :7621-7636
[8]   Facing death in the fly: Genetic analysis of apoptosis in Drosophila [J].
McCall, K ;
Steller, H .
TRENDS IN GENETICS, 1997, 13 (06) :222-226
[9]   Activation of the reaper gene during ectopic cell killing in Drosophila [J].
Nordstrom, W ;
Chen, P ;
Steller, H ;
Abrams, JM .
DEVELOPMENTAL BIOLOGY, 1996, 180 (01) :213-226
[10]   Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 [J].
Ollmann, M ;
Young, LM ;
Di Como, CJ ;
Karim, F ;
Belvin, M ;
Robertson, S ;
Whittaker, K ;
Demsky, M ;
Fisher, WW ;
Buchman, A ;
Duyk, G ;
Friedman, L ;
Prives, C ;
Kopczynski, C .
CELL, 2000, 101 (01) :91-101