RETRACTED: Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome (Retracted article. See vol. 334, pg. 1636, 2011)

被引：392

作者：

Lombardi, Vincent C. ^{[1
]}

Ruscetti, Francis W. ^{[2
]}

Das Gupta, Jaydip ^{[3
]}

Pfost, Max A. ^{[1
]}

Hagen, Kathryn S. ^{[1
]}

Peterson, Daniel L. ^{[1
]}

Ruscetti, Sandra K. ^{[4
]}

Bagni, Rachel K. ^{[5
]}

Petrow-Sadowski, Cari ^{[6
]}

Gold, Bert ^{[2
]}

Dean, Michael ^{[2
]}

Silverman, Robert H. ^{[3
]}

Mikovits, Judy A. ^{[1
]}

机构：

[1] Whittemore Peterson Inst, Reno, NV 89557 USA

[2] NCI, Expt Immunol Lab, Frederick, MD 21701 USA

[3] Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA

[4] NCI, Lab Canc Prevent, Frederick, MD 21701 USA

[5] NCI, Adv Technol Program, Frederick, MD 21701 USA

[6] NCI, Basic Res Program, Sci Applicat Int Corp, Frederick, MD 21701 USA

来源：

SCIENCE | 2009年 / 326卷 / 5952期

关键词：

MURINE LEUKEMIA-VIRUS; FOCUS-FORMING VIRUS; CENTRIFUGAL ENHANCEMENT; GROWTH-FACTOR; RNASE-L; GENE; LYMPHOMA; REGION;

D O I：

10.1126/science.1179052

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in 68 of 101 patients (67%) as compared to 8 of 218 (3.7%) healthy controls. Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell-associated and cell-free transmission of the virus are possible. Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines after their exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients. These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.

引用

页码：585 / 589

页数：5

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[1] RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases [J].