The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD 170292

被引：12

作者：

Bernad, N

Burgaud, BGM

Horwell, DC

Lewthwaite, RA

Martinez, J

Pritchard, MC

机构：

[1] Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

[2] CCIPE, Fac Pharm, F-34060 Montpellier, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00198-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：1245 / 1248

页数：4

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