Capillary electrophoresis for the analysis of non-steroidal anti-inflammatory drugs

被引：68

作者：

Macia, Alba

Borrull, Francesc

Calull, Marta

Aguilar, Carme

机构：

[1] Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, E-43007 Tarragona, C/Marcellí Domingo s/n

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2007年 / 26卷 / 02期

关键词：

biological sample; capillary electrophoresis; CE; non-steroidal anti-inflammatory drug; NSAID; preconcentration strategy; water sample;

D O I：

10.1016/j.trac.2006.11.011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Thousands of tons of pharmacologically active substances are used annually to treat or to prevent illnesses, or to help people with the stress of modern life. Non-steroidal anti-inflammatory drugs (NSAIDs) are the group most often used in human health care, since they are available without prescription for treatment of fever and minor pain. The present review addresses the use of various modes of capillary electrophoresis (CE) for the analysis of NSAIDs. Special attention is paid to those aspects that decrease the limits of detection of these drugs by using an electrophoretic or a chromatographic approach to preconcentration. We also examine application of CE to the analysis of NSAIDs from pharmaceutical preparations, biological samples and water samples with their sample pre-treatments. Finally, we briefly outline future trends. © 2006 Elsevier Ltd. All rights reserved.

引用

页码：133 / 153

页数：21

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