Diastereoselective addition of organozinc reagents to chiral α-imino esters

被引：39

作者：

Chiev, KP ^{[1
]}

Roland, S ^{[1
]}

Mangeney, P ^{[1
]}

机构：

[1] Univ Paris 06, Lab Chim Organoelements, UMR 7611, F-75252 Paris 05, France

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(02)00587-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The addition of organozinc reagents to chiral a-imino esters pre-complexed with zinc bromide, occurred with complete regioselectivity at the imino carbon. The influence of the solvent, temperature and different chiral auxiliaries was studied. The best diastereoselectivities were obtained in Et2O or CH2Cl2 at 0degreesC, using phenylglycinol methyl ether as the chiral inductor. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2205 / 2209

页数：5

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