Pharmacology of drugs formulated with DepoFoaM™ -: A sustained release drug delivery system for parenteral administration using multivesicular liposome technology

被引：122

作者：

Angst, Martin S. ^{[1
]}

Drover, David R. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA

来源：

CLINICAL PHARMACOKINETICS | 2006年 / 45卷 / 12期

关键词：

D O I：

10.2165/00003088-200645120-00002

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Lamellar liposome technology has been used for several decades to produce sustained-release drug formulations for parenteral administration. Multivesicular liposomes are structurally distinct from lamellar liposomes and consist of an aggregation of hundreds of water-filled polyhedral compartments separated by bi-layered lipid septa. The unique architecture of multivesicular liposomes allows encapsulating drug with greater efficiency, provides robust structural stability and ensures reliable, steady and prolonged drug release.

引用

页码：1153 / 1176

页数：24

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