Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation

被引：255

作者：

Herbert, Shane P. ^{[1
,2
,3
,4
,5
]}

Huisken, Jan ^{[1
,2
,3
]}

Kim, Tyson N. ^{[6
]}

Feldman, Morri E. ^{[7
]}

Houseman, Benjamin T. ^{[8
,9
]}

Wang, Rong A. ^{[6
]}

Shokat, Kevan M. ^{[8
,9
]}

Stainier, Didier Y. R. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, Program Dev Biol, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Genet, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, Program Human Genet, San Francisco, CA 94158 USA

[4] Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England

[5] Univ Leeds, Inst Mol & Cellular Biol, Fac Biol Sci, Leeds LS2 9JT, W Yorkshire, England

[6] Univ Calif San Francisco, Dept Surg, Div Vasc Surg, Lab Accelerated Vasc Res, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Grad Grp Biophys, San Francisco, CA 94158 USA

[8] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94158 USA

[9] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94158 USA

来源：

SCIENCE | 2009年 / 326卷 / 5950期

基金：

英国惠康基金;

关键词：

ENDOTHELIAL-GROWTH-FACTOR; VASCULAR MORPHOGENESIS; NOTCH; P110-ALPHA; ANGIOGENESIS; EPHRINB2; HEDGEHOG; SUBUNIT; PATHWAY; ROLES;

D O I：

10.1126/science.1178577

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Blood vessels form de novo (vasculogenesis) or upon sprouting of capillaries from preexisting vessels (angiogenesis). With high-resolution imaging of zebrafish vascular development, we uncovered a third mode of blood vessel formation whereby the first embryonic artery and vein, two unconnected blood vessels, arise from a common precursor vessel. The first embryonic vein formed by selective sprouting of progenitor cells from the precursor vessel, followed by vessel segregation. These processes were regulated by the ligand EphrinB2 and its receptor EphB4, which are expressed in arterial-fated and venous-fated progenitors, respectively, and interact to orient the direction of progenitor migration. Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development.

引用

页码：294 / 298

页数：5

共 26 条

[1]

Molecular regulation of angiogenesis and lymphangiogenesis [J].

Adams, Ralf H. ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (06) :464-478

[2]

The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration [J].

Adams, RH ;

Diella, F ;

Hennig, S ;

Helmbacher, F ;

Deutsch, U ;

Klein, R .

CELL, 2001, 104 (01) :57-69

[3]

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis [J].

Adams, RH ;

Wilkinson, GA ;

Weiss, C ;

Diella, F ;

Gale, NW ;

Deutsch, U ;

Risau, W ;

Klein, R .

GENES & DEVELOPMENT, 1999, 13 (03) :295-306

[4]

Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development [J].

Beis, D ;

Bartman, T ;

Jin, SW ;

Scott, IC ;

D'Amico, LA ;

Ober, EA ;

Verkade, H ;

Frantsve, J ;

Field, HA ;

Wehman, A ;

Baier, H ;

Tallafuss, A ;

Bally-Cuif, L ;

Chen, JN ;

Stainier, DYR ;

Jungblut, B .

DEVELOPMENT, 2005, 132 (18) :4193-4204

[5]

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase [J].

Bi, L ;

Okabe, I ;

Bernard, DJ ;

Wynshaw-Boris, A ;

Nussbaum, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10963-10968

[6]

Sox18 and Sox7 play redundant roles in vascular development [J].

Cermenati, Solei ;

Moleri, Silvia ;

Cimbro, Simona ;

Corti, Paola ;

Del Giacco, Luca ;

Amodeo, Roberta ;

Dejana, Elisabetta ;

Koopman, Peter ;

Cotelli, Franco ;

Beltrame, Monica .

BLOOD, 2008, 111 (05) :2657-2666

[7]

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly [J].

Foo, SS ;

Turner, CJ ;

Adams, S ;

Compagni, A ;

Aubyn, D ;

Kogata, N ;

Lindblom, P ;

Shani, M ;

Zicha, D ;

Adams, RH .

CELL, 2006, 124 (01) :161-173

[8]

Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos [J].

Gering, M ;

Patient, R .

DEVELOPMENTAL CELL, 2005, 8 (03) :389-400

[9]

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration [J].

Graupera, Mariona ;

Guillermet-Guibert, Julie ;

Foukas, Lazaros C. ;

Phng, Li-Kun ;

Cain, Robert J. ;

Salpekar, Ashreena ;

Pearce, Wayne ;

Meek, Stephen ;

Millan, Jaime ;

Cutillas, Pedro R. ;

Smith, Andrew J. H. ;

Ridley, Anne J. ;

Ruhrberg, Christiana ;

Gerhardt, Holger ;

Vanhaesebroeck, Bart .

NATURE, 2008, 453 (7195) :662-666

[10]

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis [J].

Hellstroem, Mats ;

Phng, Li-Kun ;

Hofmann, Jennifer J. ;

Wallgard, Elisabet ;

Coultas, Leigh ;

Lindblom, Per ;

Alva, Jackelyn ;

Nilsson, Ann-Katrin ;

Karlsson, Linda ;

Gaiano, Nicholas ;

Yoon, Keejung ;

Rossant, Janet ;

Iruela-Arispe, M. Luisa ;

Kalen, Mattias ;

Gerhardt, Holger ;

Betsholtz, Christer .

NATURE, 2007, 445 (7129) :776-780

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