Prodrug-activating systems in suicide gene therapy

被引:169
作者
Springer, CJ [1 ]
Niculescu-Duvaz, I [1 ]
机构
[1] Inst Canc Res, Canc Res Campaign Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England
关键词
D O I
10.1172/JCI10001
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:1161 / 1167
页数:7
相关论文
共 33 条
[1]   Immunomodulation of cancer: potential use of selectively replicating agents [J].
Agha-Mohammadi, S ;
Lotze, MT .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1173-1176
[2]   Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells [J].
Balzarini, J ;
Degreve, B ;
Andrei, G ;
Neyts, J ;
Sandvold, M ;
Myhren, F ;
de Clercq, E .
GENE THERAPY, 1998, 5 (03) :419-426
[3]   Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy [J].
Black, ME ;
Newcomb, TG ;
Wilson, HMP ;
Loeb, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3525-3529
[4]  
BLANCHE F, 1997, Patent No. 9735024
[5]   Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase [J].
Boucher, PD ;
Ruch, RJ ;
Shewach, DS .
HUMAN GENE THERAPY, 1998, 9 (06) :801-814
[6]   Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954 [J].
Bridgewater, JA ;
Springer, CJ ;
Knox, RJ ;
Minton, NP ;
Michael, NP ;
Collins, MK .
EUROPEAN JOURNAL OF CANCER, 1995, 31A (13-14) :2362-2370
[7]  
Chen L, 1997, CANCER RES, V57, P4830
[8]  
Chen SH, 1996, CANCER RES, V56, P3758
[9]   The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies [J].
Denny, WA ;
Wilson, WR .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1998, 50 (04) :387-394
[10]   Improving enzymes for cancer gene therapy [J].
Encell, LP ;
Landis, DM ;
Loeb, LA .
NATURE BIOTECHNOLOGY, 1999, 17 (02) :143-147