Rho proteins: Targets for bacterial toxins

被引：134

作者：

Aktories, K

机构：

[1] Inst. fur Pharmakol. and Toxikol., Albert-Ludwigs-Univ. Freiburg, D-79104 Freiburg

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(97)01067-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GTP-binding proteins of the Rho family are regulators of the actin cytoskeleton and molecular switches in various signal transduction pathways. The Rho proteins are targets for bacterial protein toxins that either inactivate GTPases by ADP-ribosylation or glucosylation, or activate them by deamidation. Rho proteins play essential roles in host cell invasion by bacteria.

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页码：282 / 288

页数：7

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