Transplantation for amyloidosis

被引：63

作者：

Gertz, Morie A. ^{[1
]}

Lacy, Martha Q. ^{[1
]}

Dispenzieri, Angela ^{[1
]}

Hayman, Suzanne R. ^{[1
]}

Kumar, Shaji ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Div Hematol, Rochester, MN 55905 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2007年 / 19卷 / 02期

关键词：

amyloidosis; multiple myeloma; nephrotic syndrome; restrictive cardiomyopathy; stem cell transplantation;

D O I：

10.1097/CCO.0b013e32801494c6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose of review High-dose chemotherapy increasingly is being used for the management of patients with immunoglobulin ligh-chain amyloidosis. We describe nearly 300 patients who had treatment combining high-dose chemotherapy and stem cell transplantation at Mayo Clinic and review the recent literature. Recent findings We review outcomes, engraftment data, and predictors of early mortality. The survival benefit of transplantation, however, has not been verified in a phase III clinical trial. Summary Partial response rates and complete response rates are prognosticators of survival for patients with amyloidosis. These rates are much higher for patients who receive high-dose therapy and transplantation.

引用

页码：136 / 141

页数：6

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