Cablinosides A and B, Two Glycosidic Phenylacetic Acid Derivatives from the Leaves of Pogostemon cablin

被引：11

作者：

Huang, Xiao-Jun ^{[1
,2
,3
]}

Li, Ping ^{[1
]}

Yin, Zhi-Qi ^{[4
]}

Lu, Jin-Jian ^{[1
]}

Lin, Li-Gen ^{[1
]}

Wang, Ying ^{[2
,3
]}

Ye, Wen-Cai ^{[2
,3
]}

Zhang, Qing-Wen ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[4] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept TCMs Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 05期

基金：

国家重点研发计划;

关键词：

Pogostemon cablin; Cablinosides A and B; patchouli; cytotoxicity; inhibitors; phytochemistry; structure elucidation; MIGRATION;

D O I：

10.1002/cbdv.201900137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A pair of new glycosidic epimers, cablinosides A (1a) and B (1b) were isolated from the leaves of Pogostemon cablin. The structures with absolute configurations of 1a and 1b were elucidated by extensive NMR investigation, and quantum chemical CD calculations. The epimer mixture 1 showed moderate alpha -glucosidase inhibitory activity and no significant cytotoxic activity against HepG2 cells.

引用

页数：6

共 20 条

[1]

Bruhn T, 2017, SpecDis version 1.71

[2]

STRUCTURES OF TWO ALKALOIDS FROM PATCHOULI OIL [J].