Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation

被引：13

作者：

Hosoda, A

Nomura, E

Murakami, A

Koshimizu, K

Ohigashi, H

Mizuno, K

Taniguchi, H

机构：

[1] Ind Technol Ctr Wakayama Prefecture, Wakayama 6496261, Japan

[2] Kinki Univ, Fac Biol Oriented Sci & Technol, Dept Biotechnol Sci, Wakayama 6496493, Japan

[3] Kyoto Univ, Grad Sch Agr, Div Appl Sci, Kyoto 6068502, Japan

[4] Univ Osaka Prefecture, Coll Engn, Dept Appl Chem, Osaka 5998531, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00252-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ester compounds consisting of ferulic acid and myo-inositol, obtained from rice bran, were synthesized. The inhibitory effects of these feruloyl-myo-inositols on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced superoxide (O-2(-)) generation were examined using differentiated HL-60 cells. Among the derivatives tested, only 3,4,5,6-tetra-O-acetyl- 1,2-di-O-[3-(4'-acetoxy-3'-methoxyphenyl)-2-propenoyl]-myo-inositol (3) showed a distinct inhibitory activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1439 / 1442

页数：4

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