Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"

被引：169

作者：

Chartrel, N.

Alvear-Perez, R.

Leprince, J.

Iturrioz, X.

Reaux-Le Goazigo, A.

Audinot, V.

Chomarat, P.

Coge, F.

Nosjean, O.

Rodriguez, M.

Galizzi, J. P.

Boutin, J. A. ^{[1
]}

Vaudry, H.

Llorens-Cortes, C.

机构：

[1] Univ Rouen, Lab Cellular & Mol Neuroendocrinol, INSERM, U413, F-76821 Mont St Aignan, France

[2] Univ Rouen, European Inst Peptide Res, IFRMP 23, F-76821 Mont St Aignan, France

[3] INSERM, U691, F-75005 Paris, France

[4] Coll France, F-75005 Paris, France

[5] Ctr Rech Croissy, IdRS, F-78290 Croissy Sur Seine, France

来源：

SCIENCE | 2007年 / 315卷 / 5813期

关键词：

D O I：

10.1126/science.1135047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zhang et al. ( Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I-125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays ( cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

引用

页数：2

共 3 条

[1] GPR39 signaling is stimulated by zinc ions but not by obestatin [J].