Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs

被引：2

作者：

Bao, Huixin

Wang, Xiaohui

Yu, Haijia

Fu, Manliang

Qu, Xiaogang ^{[1
]}

Zheng, Yongchen

Ren, Jinsong

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Div Biol Inorgan Chem, Key Lab Rare Earth Chem & Phys,Grad Sch, Changchun 130022, Peoples R China

[2] Jilin Univ, Cent Lab, Hosp 2, Changchun 130023, Peoples R China

来源：

CHEMICAL PHYSICS LETTERS | 2007年 / 436卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.cplett.2007.01.050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Over expression of cyclin A in human tumors has been linked to cancer by various experimental lines of evidence. However, physical and spectral characterization of the human cyclin A gene and its interactions with anticancer drugs have not been reported. Our gene sequence analysis, singular value decomposition method and melting studies in the presence of antitumor agents, daunomycin, doxorubicin and Hoechst 33258 showed that cyclin A gene had both AT-rich and GC-rich domains. For a ligand with unknown DNA binding specificity, this gene sequence can be used to differentiate its DNA binding preference. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：252 / 257

页数：6

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