Variation resources at UC Santa Cruz

被引:11
作者
Thomas, Daryl J.
Trumbower, Heather
Kern, Andrew D.
Rhead, Brooke L.
Kuhn, Robert M.
Haussler, David
Kent, W. James
机构
[1] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA
[3] Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA
关键词
D O I
10.1093/nar/gkl953
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The variation resources within the University of California Santa Cruz Genome Browser include polymorphism data drawn from public collections and analyses of these data, along with their display in the context of other genomic annotations. Primary data from dbSNP is included for many organisms, with added information including genomic alleles and orthologous alleles for closely related organisms. Display filtering and coloring is available by variant type, functional class or other annotations. Annotation of potential errors is highlighted and a genomic alignment of the variant's flanking sequence is displayed. HapMap allele frequencies and linkage disequilibrium (LD) are available for each HapMap population, along with non-human primate alleles. The browsing and analysis tools, downloadable data files and links to documentation and other information can be found at http://genome.ucsc.edu/.
引用
收藏
页码:D716 / D720
页数:5
相关论文
共 41 条
[1]   Population history and natural selection shape patterns of genetic variation in 132 genes [J].
Akey, JM ;
Eberle, MA ;
Rieder, MJ ;
Carlson, CS ;
Shriver, MD ;
Nickerson, DA ;
Kruglyak, L .
PLOS BIOLOGY, 2004, 2 (10) :1591-1599
[2]   Genomic microarrays in human genetic disease and cancer [J].
Albertson, DG ;
Pinkel, D .
HUMAN MOLECULAR GENETICS, 2003, 12 :R145-R152
[3]   A haplotype map of the human genome [J].
Altshuler, D ;
Brooks, LD ;
Chakravarti, A ;
Collins, FS ;
Daly, MJ ;
Donnelly, P ;
Gibbs, RA ;
Belmont, JW ;
Boudreau, A ;
Leal, SM ;
Hardenbol, P ;
Pasternak, S ;
Wheeler, DA ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Zeng, CQ ;
Gao, Y ;
Hu, HR ;
Hu, WT ;
Li, CH ;
Lin, W ;
Liu, SQ ;
Pan, H ;
Tang, XL ;
Wang, J ;
Wang, W ;
Yu, J ;
Zhang, B ;
Zhang, QR ;
Zhao, HB ;
Zhao, H ;
Zhou, J ;
Gabriel, SB ;
Barry, R ;
Blumenstiel, B ;
Camargo, A ;
Defelice, M ;
Faggart, M ;
Goyette, M ;
Gupta, S ;
Moore, J ;
Nguyen, H ;
Onofrio, RC ;
Parkin, M ;
Roy, J ;
Stahl, E ;
Winchester, E ;
Ziaugra, L ;
Shen, Y .
NATURE, 2005, 437 (7063) :1299-1320
[4]   Segmental duplications: Organization and impact within the current Human Genome Project assembly [J].
Bailey, JA ;
Yavor, AM ;
Massa, HF ;
Trask, BJ ;
Eichler, EE .
GENOME RESEARCH, 2001, 11 (06) :1005-1017
[5]   Haploview: analysis and visualization of LD and haplotype maps [J].
Barrett, JC ;
Fry, B ;
Maller, J ;
Daly, MJ .
BIOINFORMATICS, 2005, 21 (02) :263-265
[6]   Tandem repeats finder: a program to analyze DNA sequences [J].
Benson, G .
NUCLEIC ACIDS RESEARCH, 1999, 27 (02) :573-580
[7]   Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease [J].
Botstein, D ;
Risch, N .
NATURE GENETICS, 2003, 33 (Suppl 3) :228-237
[8]   A high-resolution survey of deletion polymorphism in the human genome [J].
Conrad, DF ;
Andrews, TD ;
Carter, NP ;
Hurles, ME ;
Pritchard, JK .
NATURE GENETICS, 2006, 38 (01) :75-81
[9]   Evidence for substantial fine-scale variation in recombination rates across the human genome [J].
Crawford, DC ;
Bhangale, T ;
Li, N ;
Hellenthal, G ;
Rieder, MJ ;
Nickerson, DA ;
Stephens, M .
NATURE GENETICS, 2004, 36 (07) :700-706
[10]   High-resolution haplotype structure in the human genome [J].
Daly, MJ ;
Rioux, JD ;
Schaffner, SE ;
Hudson, TJ ;
Lander, ES .
NATURE GENETICS, 2001, 29 (02) :229-232