Eicosanoids and the large intestine

被引：32

作者：

Krause, W

DuBois, RN ^{[1
]}

机构：

[1] Vanderbilt Canc Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Cell Biol, Vanderbilt Canc Ctr, Nashville, TN 37232 USA

[3] VA Med Ctr, Nashville, TN 37232 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2000年 / 61卷 / 3-4期

关键词：

eicosanoids; colon; secretion; ion transport; inflammatory bowel disease; colorectal cancer;

D O I：

10.1016/S0090-6980(00)00069-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future. The purpose of this report is to provide a brief overview of the role of eicosanoids in the colon and rectum, This information has been organized according to both functional and disease-related categories. The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：145 / 161

页数：17

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