Metabolomics Applied to Diabetes Research Moving From Information to Knowledge

被引：253

作者：

Bain, James R.

Stevens, Robert D.

Wenner, Brett R.

Ilkayeva, Olga

Muoio, Deborah M.

Newgard, Christopher B. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA

来源：

DIABETES | 2009年 / 58卷 / 11期

基金：

美国国家卫生研究院;

关键词：

STIMULATED INSULIN-SECRETION; NMR ISOTOPOMER ANALYSIS; MASS-SPECTROMETRY; MYOCARDIAL-INFARCTION; H-1-NMR METABONOMICS; SHOTGUN LIPIDOMICS; PROFILING REVEALS; CRUDE EXTRACTS; ADIPOSE-TISSUE; WEIGHT-LOSS;

D O I：

10.2337/db09-0580

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：2429 / 2443

页数：15

共 84 条

[1] Bioinformatics analysis of targeted metabolomics - Uncovering old and new tales of diabetic mice under medication [J].

Altmaier, Elisabeth ;

Ramsay, Steven L. ;

Graber, Armin ;

Mewes, Hans-Werner ;

Weinberger, Klaus M. ;

Suhre, Karsten .

ENDOCRINOLOGY, 2008, 149 (07) :3478-3489

[2] Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance [J].

An, J ;

Muoio, DM ;

Shiota, M ;

Fujimoto, Y ;

Cline, GW ;

Shulman, GI ;

Koves, TR ;

Stevens, R ;

Millington, D ;

Newgard, CB .

NATURE MEDICINE, 2004, 10 (03) :268-274

[3] A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome [J].

Atherton, Helen J. ;

Bailey, Nigel J. ;

Zhang, Wen ;

Taylor, John ;

Major, Hilary ;

Shockcor, John ;

Clarke, Kieran ;

Griffin, Julian L. .

PHYSIOLOGICAL GENOMICS, 2006, 27 (02) :178-186

[4] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[5] Metabonomic Variations in the Drug-Treated Type 2 Diabetes Mellitus Patients and Healthy Volunteers [J].

Bao, Yuqian ;

Zhao, Tie ;

Wang, Xiaoyan ;

Qiu, Yunping ;

Su, Mingming ;

Jia, Weiping ;

Jia, Wei .

JOURNAL OF PROTEOME RESEARCH, 2009, 8 (04) :1623-1630

[6] Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue [J].

Boucher, A ;

Lu, DH ;

Burgess, SC ;

Telemaque-Potts, S ;

Jensen, MV ;

Mulder, H ;

Wang, MY ;

Unger, RH ;

Sherry, AD ;

Newgard, CB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) :27263-27271

[7] Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle [J].

Bouzakri, Karim ;

Austin, Reginald ;

Rune, Anna ;

Lassman, Michael E. ;

Garcia-Roves, Pablo M. ;

Berger, Joel P. ;

Krook, Anna ;

Chibalin, Alexander V. ;

Zhang, Bei B. ;

Zierath, Juleen R. .

DIABETES, 2008, 57 (06) :1508-1516

[8]

Brindle JT, 2002, NAT MED, V8, P1439, DOI 10.1038/nm802

[9] Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance [J].

Bruce, Clinton R. ;

Hoy, Andrew J. ;

Turner, Nigel ;

Watt, Matthew J. ;

Allen, Tamara L. ;

Carpenter, Kevin ;

Cooney, Gregory J. ;

Febbraio, Mark A. ;

Kraegen, Edward W. .

DIABETES, 2009, 58 (03) :550-558

[10] Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism [J].

Cao, Haiming ;

Gerhold, Kristin ;

Mayers, Jared R. ;

Wiest, Michelle M. ;

Watkins, Steven M. ;

Hotamisligil, Goekhan S. .

CELL, 2008, 134 (06) :933-944

← 1 2 3 4 5 6 7 8 9 →