Spongistatin synthetic studies .1. Construction of a C(29-48) subtarget

被引：67

作者：

Smith, AB ^{[1
]}

Zhuang, LH ^{[1
]}

Brook, CS ^{[1
]}

Boldi, AM ^{[1
]}

McBriar, MD ^{[1
]}

Moser, WH ^{[1
]}

Murase, N ^{[1
]}

Nakayama, K ^{[1
]}

Verhoest, PR ^{[1
]}

Lin, QY ^{[1
]}

机构：

[1] UNIV PENN,MONELL CHEM SENSES CTR,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 50期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10499-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this Letter, the first in a series of three, we outline our overall strategy and describe the assembly of a C(29-48) EF-ring advanced intermediate for the total synthesis of the spongistatins, rare and structurally unique polyether macrolides with unprecedented antitumor activity. (C) 1997 Elsevier Science Ltd.

引用

页码：8667 / 8670

页数：4

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