Sensing life:: regulation of sensory neuron survival by neurotrophins

被引：50

作者：

Kirstein, M ^{[1
]}

Fariñas, I ^{[1
]}

机构：

[1] Univ Valencia, Dept Biol Celular, Burjassot 46100, Spain

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 11期

关键词：

neuronal survival; dorsal root ganglia; cranial ganglia; knockout; transgenic mice;

D O I：

10.1007/PL00012506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophins are a family of structurally and functionally related neurotrophic factors which, in mammals, include: nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and NT-4/5. In addition to their canonical role in promoting neuronal survival, these molecules appear to regulate multiple aspects of the development of the nervous system in vertebrates, including neuronal differentiation, axon elongation and target innervation, among others. Actions of neurotrophins and of their receptors in vivo are being analyzed by loss-of-function or gain-of-function experiments in mice. Here, we review the phenotypes of the primary sensory system in these mutant mouse strains and the different strategies specifically involved in the regulation of neuronal survival by neurotrophins in this portion of the nervous system.

引用

页码：1787 / 1802

页数：16

共 109 条

[1] Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation [J].