Molecular regulation of mitochondrial dynamics in cardiac disease

被引：139

作者：

Nan, Jinliang ^{[1
]}

Zhu, Wei ^{[1
]}

Rahman, M. S. ^{[2
]}

Liu, Mingfei ^{[1
]}

Li, Dan ^{[1
]}

Su, Shengan ^{[1
]}

Zhang, Na ^{[1
]}

Hu, Xinyang ^{[1
]}

Yu, Hong ^{[1
]}

Gupta, Mahesh P. ^{[3
]}

Wang, Jian'an ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Cardiovasc Key Lab Zhejiang Prov,Dept Cardiol, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Clin Res Ctr, Hangzhou 310009, Zhejiang, Peoples R China

[3] Dept Surg, Chicago, IL USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2017年 / 1864卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Mitochondrial dynamics; Ischemia-reperfusion; Heart failure; Diabetic cardiomyopathy; ISCHEMIA-REPERFUSION INJURY; HUMAN SKELETAL-MUSCLE; DIABETIC HUMAN HEART; CELL-DEATH; MITOFUSIN; OXIDATIVE-PHOSPHORYLATION; PERMEABILITY TRANSITION; EMBRYONIC-DEVELOPMENT; INSULIN-RESISTANCE; O-GLCNACYLATION;

D O I：

10.1016/j.bbamcr.2017.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mitochondrial homeostasis is critical for keeping functional heart in response to metabolic or environmental stresses. Mitochondrial fission and fusion (mitochondrial dynamics) play essential roles in maintaining mitochondrial homeostasis, defects in mitochondrial dynamics lead to cardiac diseases such as ischemia-reperfusion injury (IRI), heart failure and diabetic cardiomyopathy. Mitochondrial dynamics is determined by mitochondrial fission and fusion proteins, including OPA1, mitofusins and Drpl. These proteins are tightly regulated by a series of signaling pathways through different aspects such as transcription, post translation modifications (PTMs) and proteasome-dependent protein degradation. By modulating these mitochondrial fission and fusion proteins, mitochondria fine-tune their metabolic status to meet the energy demands of the heart. Moreover, these mitochondrial fission and fusion proteins are essential for mediating mitochondrial autophagy (mitophagy), leading to clearance of damaged mitochondria to maintain a healthy population of mitochondria in heart under stressed conditions. Mitochondrial dynamics dependent improvement in mitochondrial metabolism and quality could partially reverse the pathological conditions of heart. This review describes an overview of mechanisms on mitochondrial dynamics regulation and provides potential therapeutic targets for treating cardiovascular diseases. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1260 / 1273

页数：14

共 134 条

[1]

Characterization of OPA1 isoforms isolated from mouse tissues [J].